APP bCTF, Human, ELISA Kit

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27776
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Product Name APP bCTF, Human, ELISA Kit
Description Alzheimer's disease (AD) was first reported by A. Alzheimer, a German neuropathologist in 1907 and is considered as a major factor of senile dementia. It is known that Amyloid b (Ab; which is a major constituent of senile plaque) is cleaved from Amyloid Precursor Protein (APP; which exists in three main isoforms, APP695, APP751, and APP770) by b-secretase and subsequent y-secretase (ref.1). On the one hand, it has been also reported there is bCTF (b-secretase C-terminal fragment), fragments which are cleaved by b-secretase but not by y-secretase. It is thought that measuring bCTF, in addition to Ab, soluble APPa and APPb, also has significance in research of the metabolic pathway of APP. This ELISA can measure human APP bCTF in samples such as cultured cell lysates . This kit is a solid phase sandwich ELISA using 2 kinds of high specific antibodies. Tetra Methyl Benzidine (TMB) is used as a coloring agent (Chromogen). The strength of coloring is proportional to the quantities of Human APP bCTF.
Reactivity Human

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