| Product Name | ARFGEF2 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to ARFGEF2 |
| Synonyms | ARFGEF2 antibody; ARFGEP2 antibody; BIG2Brefeldin A-inhibited guanine nucleotide-exchange protein 2 antibody; Brefeldin A-inhibited GEP 2 antibody; ADP-ribosylation factor guanine nucleotide-exchange factor 2 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthesized peptide derived from internal of human ARFGEF2. |
| Isotype | IgG |
| Target | ARFGEF2 |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IF, WB |
| Form | liquid |
| Diluent Buffer | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot | Q9Y6D5 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background |
Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extend on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Togawa A., J. Biol. Chem. 274:12308-12315(1999). Deloukas P., Nature 414:865-871(2001). Beausoleil S.A., Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) |
| Supplier | Cusabio |
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