| Product Name | ARHGAP17 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to ARHGAP17 |
| Synonyms | ARHGAP17 antibody; RICH1 antibody; MSTP066 antibody; MSTP110 antibody; Rho GTPase-activating protein 17 antibody; Rho-type GTPase-activating protein 17 antibody; RhoGAP interacting with CIP4 homologs protein 1 antibody; RICH-1 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthesized peptide derived from internal of humanRHG17. |
| Isotype | IgG |
| Target | ARHGAP17 |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, WB |
| Form | liquid |
| Diluent Buffer | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot | Q68EM7 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background |
Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca2+-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. Richnau N., J. Biol. Chem. 276:35060-35070(2001). Ota T., Nat. Genet. 36:40-45(2004). The German cDNA consortium; Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases. |
| Supplier | Cusabio |
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