| Product Name | ARHGEF2 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to ARHGEF2 |
| Synonyms | AA408978 antibody; ARHG2 antibody; ARHG2_HUMAN antibody; ARHGEF 2 antibody; ARHGEF-2 antibody; ARHGEF2 antibody; GEF antibody; GEF H1 antibody; GEF-H1 antibody; GEFH1 antibody; Guanine nucleotide exchange factor H1 antibody; KIAA0651 antibody; Lbcl1 antibody; Lfc antibody; LFP40 antibody; MGC95068 antibody; Microtubule-regulated Rho-GEF antibody; mKIAA0651 antibody; P40 antibody; Proliferating cell nucleolar antigen p40 antibody; Protein GEF-H1 antibody; Rho guanine nucleotide exchange factor 2 antibody; rho/rac guanine nucleotide exchange factor (GEF) 2 antibody; rho/rac guanine nucleotide exchange factor 2 antibody; rho/rac guanine nucleotide exchange factor antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthesized peptide derived from internal of human ARHGEF2. |
| Isotype | IgG |
| Target | ARHGEF2 |
| Reactivity | Human, Rat |
| Applications | ELISA, WB |
| Form | liquid |
| Diluent Buffer | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot | Q92974 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background |
Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Ren Y., J. Biol. Chem. 273:34954-34960(1998). Krendel M., Nat. Cell Biol. 4:294-301(2002). Ishikawa K., DNA Res. 5:169-176(1998). |
| Supplier | Cusabio |
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