| Product Name | ARID1B Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to ARID1B |
| Synonyms | ARID1B antibody; BAF250B antibody; DAN15 antibody; KIAA1235 antibody; OSA2AT-rich interactive domain-containing protein 1B antibody; ARID domain-containing protein 1B antibody; BRG1-associated factor 250b antibody; BAF250B antibody; BRG1-binding protein hELD/OSA1 antibody; Osa homolog 2 antibody; hOsa2 antibody; p250R antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthesized peptide derived from interal of human BAF250B. |
| Isotype | IgG |
| Target | ARID1B |
| Reactivity | Human, Rat |
| Applications | ELISA, IF, WB |
| Form | liquid |
| Diluent Buffer | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot | Q8NFD5 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background |
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth By similarity. Binds DNA non-specifically. Mungall A.J., Nature 425:805-811(2003). Mangel L., J. Biol. Chem. 273:30466-30471(1998). Imbert G., Nat. Genet. 14:285-291(1996). |
| Supplier | Cusabio |
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