| Product Name | ATG4B Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to ATG4B |
| Synonyms | APG4 autophagy 4 homolog B antibody; APG4B antibody; ATG4 autophagy related 4 homolog B (S. cerevisiae) antibody; ATG4B antibody; ATG4B_HUMAN antibody; AUT like 1 cysteine endopeptidase antibody; AUT-like 1 cysteine endopeptidase antibody; AUTL1 antibody; Autophagin 1 antibody; Autophagin-1 antibody; Autophagy related 4B cysteine peptidase antibody; Autophagy related cysteine endopeptidase 1 antibody; Autophagy related protein 4 homolog B antibody; Autophagy-related cysteine endopeptidase 1 antibody; Autophagy-related protein 4 homolog B antibody; Cysteine protease ATG4B antibody; hAPG4B antibody; MGC1353 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthesized peptide derived from internal of human ATG4B. |
| Isotype | IgG |
| Target | ATG4B |
| Reactivity | Human, Mouse |
| Applications | ELISA, IHC, WB |
| Form | liquid |
| Diluent Buffer | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot | Q9Y4P1 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background |
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. Kabeya Y., J. Cell Sci. 117:2805-2812(2004). Marino G., J. Biol. Chem. 278:3671-3678(2003). Ota T.,Nat. Genet. 36:40-45(2004). |
| Supplier | Cusabio |
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