| Product Name | ATI 2341 |
|---|---|
| Description |
ATI 2341 is a pepducin targeting the C-X-C chemokine receptor type 4 (CXCR) at which it is an allosteric agonist with an EC50 of 194 nM. ATI 2341 functions as a biased ligand, favouring Gαi activation over Gα13. In contrast to the the natural CXCR4 agonist, stromal cell-derived factor-1α, ATI 2341 does not promote β-arrestin recruitment. ATI 2341 induces chemotaxis in CXCR4 expressing cells in vitro and acts as a functional antagonist to mobilise polymorphonuclear neutrophils and hematopoietic stem and progenitor cells from bone marrow niche in both mice and non-human primates. |
| Synonyms | 1337878-62-2, ATI 2341, MGYQKKLRSMTDKYRL, Pal-MGYQKKLRSMTDKYRL |
| Molecular Weight | 2256.82 Da |
| Target | Chemokine receptors |
| Amino Acid Sequence | Pal-MGYQKKLRSMTDKYRL |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 1337878-62-2 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: N-terminal palmitoyl |
| References |
Tchernychev et al (2010) Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells. Proc.Natl.Acad.Sci.U.S.A. 107 22255 PMID: 21139054Quoyer et al (2013) Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein. Proc.Natl.Acad.Sci.U.S.A. 110 E5088 PMID: 24309376Planesas et al (2015) Studying the binding interactions of allosteric agonists and antagonists of the CXCR4 receptor. J.Mol.Graph Model. 60 1 PMID: 26080355 Related areas All peptides >All chemokine receptor modulators >All adhesion molecule research categories >All immunology research categories > |
| Supplier | Isca Biochemicals Limited |
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