| Product Name | ATP5A1 Monoclonal Antibody |
|---|---|
| Description | The ATP5A1 gene encodes the _ subunit of mitochondrial ATP synthase which produces ATP from ADP in the presence of a proton gradient across the membrane. The mitochondrial ATP synthase,also known as Complex V or F1F0 ATP synthase,is a multi-subunit enzyme complex consisting of two functional domains,the F1-containing the catalytic core and the Fo- containing the membrane proton channel. F0 domain has 10 subunits: a,b,c,d,e,f,g,OSCP,A6L,and F6. F1 is composed of subunits _,_,_,_,_,and a loosely attached inhibitor protein IF1. Recently defect in ATP5A1 has been linked to the fatal neonatal mitochondrial encephalopathy. ATP5A1 is localized in the mitochondria and anti-ATP5A1 can be used as the loading control for mitochondrial or Complex V proteins. This antibody recognizes the endogenous ATP5A1 protein in lysates from various cell lines and tissues. |
| Synonyms | ATP5A,ATP5A1,ATP5AL2,ATPM,hATP1,MOM2,OMR,ORM |
| Host | Mouse |
| Clone | 555 |
| Immunogen | Fusion protein of ATP5A1 |
| Isotype | IgG2b |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IF, IHC, WB |
| Form | PBS with 0.02% sodium azide, 50% glycerol, PH7.3 |
| Uniprot | P25705 |
| Background | The ATP5A1 gene encodes the _ subunit of mitochondrial ATP synthase which produces ATP from ADP in the presence of a proton gradient across the membrane. The mitochondrial ATP synthase,also known as Complex V or F1F0 ATP synthase,is a multi-subunit enzyme complex consisting of two functional domains,the F1-containing the catalytic core and the Fo- containing the membrane proton channel. F0 domain has 10 subunits: a,b,c,d,e,f,g,OSCP,A6L,and F6. F1 is composed of subunits _,_,_,_,_,and a loosely attached inhibitor protein IF1. Recently defect in ATP5A1 has been linked to the fatal neonatal mitochondrial encephalopathy. ATP5A1 is localized in the mitochondria and anti-ATP5A1 can be used as the loading control for mitochondrial or Complex V proteins. This antibody recognizes the endogenous ATP5A1 protein in lysates from various cell lines and tissues. |
| Supplier | Elabscience |
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