| Product Name | AurB/C Polyclonal Antibody |
|---|---|
| Description | AURKB encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene.AURKB (Aurora Kinase B) is a Protein Coding gene. Diseases associated with AURKB include Lung Mucoepidermoid Carcinoma and Neuroblastoma, Susceptibility. Among its related pathways are Regulation of TP53 Activity and Aurora B signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AURKC. AURKC encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants.AURKC (Aurora Kinase C) is a Protein Coding gene. Diseases associated with AURKC include Spermatogenic Failure 5 and Macrozoospermia. Among its related pathways are Aurora B signaling and Sweet Taste Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AURKB. |
| Synonyms | AURKB, AIK2, AIM1, AIRK2, ARK2, STK1, STK12, STK5, Aurora kinase B, Aurora 1, Aurora- and IPL1-like midbody-associated protein 1, AIM-1, Aurora/IPL1-related kinase 2, ARK-2, Aurora-related kinase 2, STK-1, Serine/threonine-protein kinase 12 |
| Host | Rabbit |
| Immunogen | Synthesized peptide derived from human ARK-2/3 around the non-phosphorylation site of Thr236/202. |
| Isotype | IgG |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IHC, WB |
| Form | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4 |
| Uniprot | Q96GD4/Q9UQB9 |
| Background |
AURKB encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene.AURKB (Aurora Kinase B) is a Protein Coding gene. Diseases associated with AURKB include Lung Mucoepidermoid Carcinoma and Neuroblastoma, Susceptibility. Among its related pathways are Regulation of TP53 Activity and Aurora B signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AURKC. AURKC encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants.AURKC (Aurora Kinase C) is a Protein Coding gene. Diseases associated with AURKC include Spermatogenic Failure 5 and Macrozoospermia. Among its related pathways are Aurora B signaling and Sweet Taste Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AURKB. |
| Supplier | Elabscience |
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