AURKC Antibody, FITC conjugated

Category: Antibodies
Catalog
CSB-PA002460LC01HU
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Product Name AURKC Antibody, FITC conjugated
Description Rabbit polyclonal antibody against AURKC conjugated to FITC
Synonyms AURKC antibody; AIE 2 antibody; Aie1 antibody; AIE2 antibody; AIK 3 antibody; AIK3 antibody; ARK 3 antibody; ARK-3 antibody; ARK3 antibody; Aur C antibody; AurC antibody; Aurkc antibody; AURKC_HUMAN antibody; aurora 3 antibody; Aurora C antibody; Aurora kinase C antibody; aurora related kinase 3 antibody; Aurora-related kinase 3 antibody; Aurora/Ipl1 related kinase 3 antibody; Aurora/Ipl1-related kinase 3 antibody; Aurora/Ipl1/Eg2 protein 2 antibody; EC 2.7.11.1 antibody; Serine threonine protein kinase 13 antibody; serine/threonine kinase 13 (aurora/IPL1 like) antibody; serine/threonine protein kinase aurora C antibody; Serine/threonine-protein kinase 13 antibody; Serine/threonine-protein kinase aurora-C antibody; SPGF5 antibody; STK13 antibody
Host Rabbit
Clonality Polyclonal
Conjugate FITC
Immunogen Recombinant Human Aurora kinase C protein (12-143AA)
Isotype IgG
Target AURKC
Reactivity Human
Applications ELISA, Dot Blot
Form Liquid
Diluent Buffer Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Uniprot Q9UQB9
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Background Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
Supplier Cusabio

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