| Product Name | Autocamtide-2-related inhibitory peptide |
|---|---|
| Description |
Autocamtide-2-related inhibitory peptide is a selective and potent calmodulin-dependent protein kinase II (CaM kinase II) inhibitor with an IC50 of 40 nM. Autocamtide-2-related inhibitory peptide is selective over PKC, PKA and CaM kinase IV, with IC50's greater than 10 μM for each. Autocamtide 2–related inhibitory peptide reverses CaMKII mediated effects in cardiac channels but does not alter INa gating. |
| Synonyms | AIP |
| Molecular Weight | 1497.76 Da |
| Target | Kinases |
| Amino Acid Sequence | KKALRRQEAVDAL |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 167114-91-2 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: None |
| References |
Ishida et al (1995) A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem.Biophys.Res.Commun. 212 806 PMID: 7626114Wagner et al (2006) Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels. J Clin Invest. 116(12) 3127 https://doi.org/10.1172/JCI26620.Ikeda et al (2019) Blockade of L-type Ca2+ channel attenuates doxorubicin-induced cardiomyopathy via suppression of CaMKII-NF-κ B pathway. Sci Rep 9 9850 https://doi.org/10.1038/s41598-019-46367-6Feng et al (2023) The CaMKII Inhibitory Peptide AIP Alleviates Renal Fibrosis Through the TGF-β/Smad and RAF/ERK Pathways. J Pharmacol Exp Ther. 386(3) 310 PMID: 37419684 Related areas All peptides >All kinase modulators >All cardiovascular research categories > |
| Supplier | Isca Biochemicals Limited |
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