| Product Name | AXIN2 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to AXIN2 |
| Synonyms | Axil antibody; Axin like protein antibody; Axin-2 antibody; Axin-like protein antibody; Axin2 antibody; AXIN2_HUMAN antibody; Axis inhibition protein 2 antibody; Conductin antibody; DKFZp781B0869 antibody; MGC10366 antibody; MGC126582 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Fusion protein of human AXIN2 |
| Isotype | IgG |
| Target | AXIN2 |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IHC, WB |
| Form | Liquid |
| Diluent Buffer | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Uniprot | Q9Y2T1 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. |
| Supplier | Cusabio |
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