BACE1, Human, Mouse, Rat, ELISA Kit

More Information
Product Name BACE1, Human, Mouse, Rat, ELISA Kit
Species Human, Mouse, Rat
Description This kit is a solid phase sandwich ELISA using 2 kinds of high specific antibodies. Tetra Methyl Benzidine (TMB) is used as coloring agent (Chromogen). The strength of coloring is in proportion to the quantities of BACE1.
Background Neuropathologically Alzheimer's disease (AD) is characterized by widespread deposition of amyloid b protein (Ab) in the cerebral cortex, and since the intracerebral accumulation of Ab is highly specific for AD and the gene mutation responsible for familial amyloidosis causes Ab to increase, Ab is thought to be of extremely great significance in the pathogenetic mechanism of AD. Ab is generated by proteolysis of the Ab precursor protein (APP), a type I membrane protein. The enzyme that cleaves it at the N-terminal is called b secretase, and it is regarded as being the protease that acts at the initial step in the production of Ab. The major b secretase has been identified as b-site APP Cleaving Enzyme 1 (BACE1), and BACE2 has been isolated as its homologue. Since increased BACE1 activity has also been reported in the brain of patients with sporadic AD, BACE1 inhibitors have been attracting attention as therapeutic agents for AD.
Intended Use It is used to measure BACE1 in brain extracts or cultured cell lysate. This product is capable of measuring each of human, mouse, rat, recombinant and native BACE1.

All Research Products are sold for laboratory RESEARCH USE ONLY and ARE NOT TO BE USED FOR HUMAN OR ANIMAL THERAPEUTIC OR DIAGNOSTIC APPLICATIONS. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. ARP American Research Products, Inc. does not submit its products for regulatory review by any government body or other organization, and we do not validate them for clinical, therapeutic or diagnostic use, or for safety and effectiveness. You are solely responsible for making sure that the way you use the products complies with applicable laws, regulations and governmental policies and for obtaining all necessary approvals, intellectual property rights, licenses and permissions that you may need related to your use. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process. ARP American Research Products, Inc. disclaims any and all representations or warranties of any kind whatsoever, express or implied, including without limitation any implied warranties of merchantability or fitness for a particular purpose, of non-infringement, or regarding results obtained through the use of any product, whether arising from a statute or otherwise in law or from a course of performance, dealing or usage of trade.

Have questions?

An ARP Customer Service Representative is happy to help!