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|Product Name||BACE1, Human, Mouse, Rat, ELISA Kit|
|Species||Human, Mouse, Rat|
|Description||This kit is a solid phase sandwich ELISA using 2 kinds of high specific antibodies. Tetra Methyl Benzidine (TMB) is used as coloring agent (Chromogen). The strength of coloring is in proportion to the quantities of BACE1.|
|Background||Neuropathologically Alzheimer's disease (AD) is characterized by widespread deposition of amyloid b protein (Ab) in the cerebral cortex, and since the intracerebral accumulation of Ab is highly specific for AD and the gene mutation responsible for familial amyloidosis causes Ab to increase, Ab is thought to be of extremely great significance in the pathogenetic mechanism of AD. Ab is generated by proteolysis of the Ab precursor protein (APP), a type I membrane protein. The enzyme that cleaves it at the N-terminal is called b secretase, and it is regarded as being the protease that acts at the initial step in the production of Ab. The major b secretase has been identified as b-site APP Cleaving Enzyme 1 (BACE1), and BACE2 has been isolated as its homologue. Since increased BACE1 activity has also been reported in the brain of patients with sporadic AD, BACE1 inhibitors have been attracting attention as therapeutic agents for AD.|
|Intended Use||It is used to measure BACE1 in brain extracts or cultured cell lysate. This product is capable of measuring each of human, mouse, rat, recombinant and native BACE1.|
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