| Product Name | Bad (Ab-136) Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to Bad (Ab-136) |
| Synonyms | Bad antibody; Bbc6Bcl2-associated agonist of cell death antibody; BAD antibody; Bcl-2-binding component 6 antibody; Bcl-xL/Bcl-2-associated death promoter antibody; Bcl2 antagonist of cell death antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Peptide sequence around aa.134~138 (S-R-S-A-P) derived from Mouse BAD. |
| Isotype | IgG |
| Target | Bad |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IHC, WB |
| Form | liquid |
| Diluent Buffer | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot | Q61337 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background |
The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. |
| Supplier | Cusabio |
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