| Product Name | Bak BH3 |
|---|---|
| Description |
Bak BH3 corresponds to amino acids 72 - 87 in the BH3 region of human Bak and is the miminal sequence for binding to Bcl-xL (B-cell lymphoma-extra large), a transmembrane molecule in the mitochondria which is a member of the Bcl-2 family and key regulator of apoptosis. Bak BH3 has high affinity binding to a surface pocket of the Bcl-XL protein that is essential for its death antagonist function. Bcl-2 is a potent suppressor of apoptosis, and its overexpression contributes to tumorigenesis in many types of human cancers. |
| Synonyms | Bak BH3 peptide, BAK peptide |
| Molecular Weight | 1724.93 Da |
| Target | Protein-protein interactions |
| Amino Acid Sequence | GQVGRQLAIIGDDINR |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 300349-67-1 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: None |
| References |
Sattler et al (1997) Structure of Bcl-xL-Bak Peptide Complex: Recognition Between Regulators of Apoptosis. Science 14 Feb 1997 983 PMID: 9020082Childs et al (2007) Apoptotic signaling induces hyperpermeability following hemorrhagic shock. Am J Physiol Heart Circ Physiol. 292(6) H3179-89 PMID: 17307990Frey et al (2008) Structure-activity relationships of Bak derived peptides: Affinity and specificity modulations by amino acid replacement, Eur. J. Medicinal Chemistry, 43(5) 966 PMID: 17692431 Related areasAll peptides >All protein-protein interaction modulators >All regulated cell death research categories >All cancer research categories > |
| Supplier | Isca Biochemicals Limited |
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