| Product Name | BAM 22P |
|---|---|
| Description | BAM 22P is a potent endogenous agonist, derived from the proenkephalin A gene, for the Mas-related G protein-coupled receptor X1 (MRGPRX1), which was originally isolated from bovine adrenal medulla. BAM 22P is a potent opioid agonist with an IC50 of 1.3 nM in guinea pig ileum. BAM 22P can produces opioid- and non-opioid receptor mediated antinociceptive effects in vivo. |
| Synonyms | proenkephalin A gene, 76622-26-9, BAM 22P, H-YGGFMRRVGRPEWWMDYQKRYG-OH, MRGPRX1, Mas-related G protein-coupled receptor X1, PN-110, PN110, YGGFMRRVGRPEWWMDYQKRYG, antinociceptive , bovine adrenal medulla |
| Molecular Weight | 2839.2 Da |
| Target | Mas-related G protein-coupled receptors |
| Amino Acid Sequence | YGGFMRRVGRPEWWMDYQKRYG |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Cas Number | 76622-26-9 |
| Storage | Store desiccated, frozen and in the dark |
| Notes | Modifications: None |
| References |
Mizuno et al (1980) A new family of endogenous €œbig€ met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (BAM-22P) and eicosapeptide (BAM-20P) with very potent opiate activity. Biochem. Biophys. Res. Comm. 97(4) 1283 PMID: 7213356Hong et al (2004) Dual effects of intrathecal BAM22 on nociceptive responses in acute and persistent pain - potential function of a novel receptor. Br.J.Pharmacol. 141 423 PMID: 14718254Solinski et al (2014) Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev. 66 570 PMID: 24867890 Related areasAll peptides >All mas-related G protein-coupled receptor modulators >All opioid receptor modulators >All pain research categories > |
| Supplier | Isca Biochemicals Limited |
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