| Product Name | BAM (8-22) |
|---|---|
| Description | BAM (8-22), also known as bovine adrenal medulla 8-22, is an endogenous peptide that was first isolated from bovine adrenal medulla and is a potent agonist for sensory neuron specific receptors, primate-specific proteins that are exclusively expressed in primary sensory neurons, with EC50 values of 28 and 14 nM for SNSR3 and SNSR4 respectively. BAM (8-22) inhibits development of morphine tolerance in rats and exerts spinal analgesic effects by an interaction with NMDA receptors. It also blocks inflammatory pain, chemical pain and downregulates the expression of spinal c-fos gene in an opioid-independent manner. In humans BAM (8-22) produces itch and nociceptive sensations in a histamine independent manner. |
| Synonyms | Bovine adrenal medulla (8-22) |
| Molecular Weight | 1971.2 Da |
| Target | Mas-related G protein-coupled receptors |
| Amino Acid Sequence | VGRPEWWMDYQKRYG |
| Form | Freeze dried sold |
| Purity | >95% by HPLC |
| Cas Number | 412961-36-5 |
| Storage | Store desiccated, frozen and in the dark |
| Notes | Modifications: None |
| References |
Simonin and Kieffer (2002) Two faces for an opioid peptide - and more receptors for pain research. Nat.Neurosci. 5 185 PMID: 11865303Chen and Ikeda (2004) Modulation of ion channels and synaptic transmission by a human sensory neuron-specific G-protein-coupled receptor, SNSR4/mrgX1, heterologously expressed in cultured rat neurons. J.Neurosci. 24 5044 PMID: 15163697Solinski et al (2014) Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev. 66 570 PMID: 24867890 Related areasAll peptides >All mas-related G protein-coupled receptor modulators >All pain research categories > |
| Supplier | Isca Biochemicals Limited |
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