| Product Name | BATF Antibody, Biotin conjugated |
|---|---|
| Description | Rabbit polyclonal antibody against BATF conjugated to Biotin |
| Synonyms | Activating transcription factor B antibody; B ATF antibody; B-ATF antibody; B-cell-activating transcription factor antibody; Basic leucine zipper transcription factor like antibody; Basic leucine zipper transcriptional factor ATF like antibody; Basic leucine zipper transcriptional factor ATF-like antibody; Batf antibody; BATF_HUMAN antibody; BATF1 antibody; SF HT activated gene 2 protein antibody; SF-HT-activated gene 2 protein antibody; SFA 2 antibody; SFA-2 antibody; SFA2 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Biotin |
| Immunogen | Recombinant human Basic leucine zipper transcriptional factor ATF-like protein (1-125AA) |
| Isotype | IgG |
| Target | BATF |
| Reactivity | Human |
| Applications | ELISA |
| Form | Liquid |
| Diluent Buffer | Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Uniprot | Q16520 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity). |
| Supplier | Cusabio |
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