| Product Name | BECN1 Antibody, Biotin conjugated |
|---|---|
| Description | Rabbit polyclonal antibody against Beclin 1 |
| Synonyms | APG6 antibody; ATG 6 antibody; ATG6 antibody; ATG6 autophagy related 6 homolog antibody; Bcl-2-interacting protein beclin antibody; Beclin 1 (coiled coil moesin like BCL2 interacting protein) antibody; Beclin 1 autophagy related antibody; Beclin-1 antibody; Beclin1 antibody; BECN 1 antibody; Becn1 antibody; BECN1_HUMAN antibody; Coiled coil myosin like BCL2 interacting protein antibody; Coiled-coil myosin-like BCL2-interacting protein antibody; GT197 antibody; Protein GT197 antibody; VPS 30 antibody; VPS30 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Biotin |
| Immunogen | Recombinant Human Beclin-1 protein (1-100AA) |
| Isotype | IgG |
| Target | BECN1 |
| Reactivity | Human |
| Applications | ELISA |
| Form | Liquid |
| Diluent Buffer | Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Uniprot | Q14457 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | Plays a central role in autophagy (PubMed:23184933). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense. |
| Supplier | Cusabio |
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