| Product Name | Bid BH3 |
|---|---|
| Description |
Bid BH3 peptide is a fragment derived from the BH3 domain of the pro-apoptotic protein Bid (BH3-interacting domain death agonist). Bid is a member of the BH3-only subset of the BCL-2 family of proteins that are critical control points in apoptosis and Bid is the first of the BH3 subset reported to bind and activate Bcl-2, Bax, and Bak. Bid serves as a death-inducing ligand that moves from the cytosol to the mitochondrial membrane to inactivate Bcl-2 or to activate Bax and the BH3 peptide domain, excised from the entire BH3-only molecule, can function as a specific death ligand itself |
| Synonyms | Bid BH3 peptide, BIDBH3 |
| Molecular Weight | 2309.59 Da |
| Target | Protein-protein interactions |
| Amino Acid Sequence | EDIIRNIARHLAQVGDSMDR |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: None |
| References |
Letai et al (2002) Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics, Cancer Cell 2(3) 183 PMID: 12242151Billen et al (2008) Bid: a Bax-like BH3 protein. Oncogene 27 S93 PMID: 19641510Jeng et al (2018) BH3-Dependent and Independent Activation of BAX and BAK in Mitochondrial Apoptosis. Curr Opin Physiol. 3 71 PMID: 30334018 Related areas All peptides >All protein-protein interaction modulators >All regulated cell death research categories >All cancer research categories > |
| Supplier | Isca Biochemicals Limited |
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