| Product Name | BING |
|---|---|
| Description |
BING is an antimicrobial peptide found in the plasma of the Japanese rice fish medaka (Oryzias latipes), derived from vacuolar protein sorting-associated protein 13D-like (Vps13D). BING possesses toxicity against a broad range of gram-positive and negative bacteria including drug resistant strains, at concentrations that have low toxicity to mammalian cell lines. BING treatment induces deregulation of periplasmic peptidyl-prolyl isomerases in gram-negative bacteria and also reduces the RNA level of cpxR, an upstream regulator of envelope stress responses which plays a crucial role in the development of antimicrobial resistance.
|
| Synonyms | Blocker of INter-membrane stress responses of Gram-negative bacteria |
| Molecular Weight | 1464.86 Da |
| Target | Antibacterials |
| Amino Acid Sequence | IRIILRAQGALKI |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: None |
| References |
Dong et al (2021) BING, a novel antimicrobial peptide isolated from Japanese medaka plasma, targets bacterial envelope stress response by suppressing cpxR expression. Sci Rep. 11(1) 12219 PMID: 34108601 Related areasAll antimicrobial peptides >All immunology categories > |
| Supplier | Isca Biochemicals Limited |
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