| Product Name | Biotin Anti-Mouse CD54 Antibody [YN1/1.7.4] |
|---|---|
| Description | CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues. |
| Synonyms | Intercellular adhesion molecule 1, Icam1, MALA-2, MyD10, CD54, Icam-1 |
| Host | Rat |
| Source | Rat |
| Clonality | Monoclonal |
| Clone | YN1/1.7.4 |
| Conjugate | Biotin |
| Isotype | Rat IgG2b |
| Reactivity | Mouse |
| Applications | FC |
| Form | PBS with 0.05% Proclin300, 1% BSA |
| Uniprot | P13597 |
| Storage | 4°C |
| Supplier | Assay Genie |
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