| Product Name | BMAP 28 (bovine) |
|---|---|
| Description | BMAP 28 is a 28 amino acid bovine myeloid cathelicidin exhibiting multiple activities against bacteria and fungi. BMAP 28 has an alpha helical structure and this acts to disrupt cell membranes, and can inhibit pan-drug-resistant Acinetobacter baumannii (PDRAB) though interaction with its outer membrane proteins (OMPs). It can also induce membrane permeabilization and death in human tumour cell lines. |
| Synonyms | AM-030, AM030 , BMAP 28, GGLRSLGRKILRAWKKYGPIIVPIIRIG, H-GGLRSLGRKILRAWKKYGPIIVPIIRIG-OH, bovine myeloid cathelicidin |
| Molecular Weight | 3131.9 Da |
| Target | Antibacterials,Antifungals |
| Amino Acid Sequence | GGLRSLGRKILRAWKKYGPIIVPIIRIG |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Storage | Store dry, frozen and desiccated |
| Notes | Modifications: None |
| References |
Risso et al (2002) BMAP-28, an antibiotic peptide of innate immunity, induces cell death through opening of the mitochondrial permeability transition pore. Mol. Cell. Biol. 22(6) 1926 PMID: 11865069Brogden et al (2007) Antimicrobial activity of cathelicidins BMAP28, SMAP28, SMAP29, and PMAP23 against Pasteurella multocida is more broad-spectrum than host species specific. Vet. Microbiol. 119 76 PMID: 16997510Guo et al (2018) A bovine myeloid antimicrobial peptide (BMAP-28) and its analogs kill pan-drug-resistant Acinetobacter baumannii by interacting with outer membrane protein A (OmpA). Medicine 97(42), e12832 PMID: 30334982 Related areasAll antimicrobial peptides >All antifungal agents >All cancer research categories >All immunology research categories > |
| Supplier | Isca Biochemicals Limited |
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