| Product Name | BMPR1B, 14-126aa, Human |
|---|---|
| Description | BMPR1B also known as bone morphogenetic protein receptor type-1B isoform b. BMPR1B is on ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. It's receptor for BMP7/OP-1 and GDF5. Recombinant human BMPR1B was expressed in E.coli and purified by using conventional chromatography techniques |
| Synonyms | Bone morphogenetic protein receptor type-1B isoform b, ALK-6, ALK6, CDw293 |
| Host | E. coli |
| Molecular Weight | 46.7kDa (428aa) confirmed by MALDI-TOF |
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSKKEDGES TAPTPRPKVL RCKCHHHCPE DSVNNICSTD GYCFTMIEED DSGLPVVTSG CLGLEGSDFQ CRDTPIPHQR RSIECCTERN ECNKDLHPTL PPLKNRDFVD GPIHHR |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in Phosphate buffered saline (pH7.4) containing 30% glycerol, 1mM DTT |
| Concentration | 0.25mg/ml (determined by Bradford assay) |
| Purity | > 80% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Ide H., et al. (1997) Oncogene 14:1377-1382. Greenman C., et al. (2007) Nature 446:153-158. |
| Background | BMPR1B also known as bone morphogenetic protein receptor type-1B isoform b. BMPR1B is on ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. It's receptor for BMP7/OP-1 and GDF5. Recombinant human BMPR1B was expressed in E.coli and purified by using conventional chromatography techniques |
| Supplier | ARP |
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