| Product Name | Bombesin |
|---|---|
| Description | Bombesin is a 14 amino acid endogenous mammalian neurotransmitter which activates three different G-protein-coupled receptors, bombesin receptor (BBR) 1, -2, and -3. Bombesin exhibits many biological effects including hormone release, stimulation of pancreatic enzyme secretion, inhibition of gastric emptying and modulation of gastric acid secretion. Bombesin also activates these receptors in the brain and together with cholecystokinin, it is the second major source of negative feedback signals that stop eating behaviour. Bombesin is also a tumour marker for small cell lung carcinoma, gastric cancer, pancreatic cancer, and neuroblastoma. |
| Synonyms | 31362-50-2, Bombesin, NR-150, NR150,, pGlu-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2 |
| Molecular Weight | 1619.9 Da |
| Target | Bombesin receptors |
| Amino Acid Sequence | XQRLGNQWAVGHLM-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Cas Number | 31362-50-2 |
| Storage | Store dark, frozen and desiccated |
| Notes | Modifications: X is pGlu, C terminal amide |
| References |
McCoy and Avery (1990) Bombesin: potential integrative peptide for feeding and satiety. Peptides 11 595 PMID: 2199952Battey and Wada (1991) Two distinct subtypes for mammalian bombesin-like peptides. TiNS 14 524 PMID: 1726343Zhang et al (2012) Evolution of Bombesin Conjugates for Targeted PET Imaging of Tumors. PLoS ONE 7(9) e44046 PMID: 23024746 Related areasAll peptides >All bombesin receptor modulators >All neuroscience research categories >All endocrinology research categories >All appetite regulation research categories >All cancer research categories > |
| Supplier | Isca Biochemicals Limited |
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