| Product Name | botA Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to botA |
| Synonyms | botA antibody; atx antibody; bonTBotulinum neurotoxin type A antibody; BoNT/A antibody; Bontoxilysin-A antibody; BOTOX antibody; Botulinum neurotoxin type A1) [Cleaved into: Botulinum neurotoxin A light chain antibody; LC antibody; EC 3.4.24.69); Botulinum neurotoxin A heavy chain antibody; HC)] antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Clostridium botulinum Botulinum neurotoxin type A protein (1-436AA) |
| Isotype | IgG |
| Target | botA |
| Reactivity | Bacteria |
| Applications | ELISA |
| Form | Liquid |
| Diluent Buffer | Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Uniprot | P0DPI0 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure. |
| Supplier | Cusabio |
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