| Product Name | BQ 3020 |
|---|---|
| Description |
BQ 3020 is a linear analogue of endothelin-1 (ET-1) which is a highly potent and selective ETB endothelin receptor agonist with Ki values of 0.18 and 970 nM at human ETB and ETA receptors. Intratumour administration of BQ 3020 can attenuate cancer pain by modulating β-endorphin release from squamous cell carcinoma cells in mouse models. |
| Synonyms | 143113-45-5, Ac-LMDKEAVYFAHLDIIW, BQ-3020, BQ3020, LMDKEAVYFAHLDIIW |
| Molecular Weight | 2006.35 Da |
| Target | Endothelin receptors |
| Amino Acid Sequence | Ac-LMDKEAVYFAHLDIIW |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 143113-45-5 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: N terminal acetyl |
| References |
Ekelund et al (1994) Effects of selective ETB-receptor stimulation on arterial, venous and capillary functions in cat skeletal muscle. Br.J.Pharmacol. 112 887 PMID: 7921617Strachan et al (2000) Constriction to ETB receptor agonists, BQ€3020 and sarafotoxin S6c, in human resistance and capacitance vessels in vivo. British J. Clinical Pharmacology 50: 27 PMID: 10886114Quang and Schmidt (2010) Peripheral endothelin B receptor agonist-induced antinociception involves endogenous opioids in mice, PAIN 149(2) 254 PMID: 20206445 Related areasAll peptides >All endothelin receptor modulators >All pain research categories >All endocrinology research categories > |
| Supplier | Isca Biochemicals Limited |
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