| Product Name | C4B Antibody, HRP conjugated |
|---|---|
| Description | Rabbit polyclonal antibody against Complement C4-B conjugated to HRP. |
| Synonyms | Basic complement C4 antibody; C2B5 antibody; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3 antibody; C4b antibody; C4B1 antibody; C4B2 antibody; C4B3 antibody; CO4B_HUMAN antibody; Complement C4 gamma chain antibody; Complement component 4B antibody; CPAMD3 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | HRP |
| Immunogen | Recombinant human Complement C4-B protein (1454-1744AA) |
| Isotype | IgG |
| Target | C4B |
| Reactivity | Human |
| Applications | ELISA |
| Form | Liquid |
| Diluent Buffer | Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Uniprot | P0C0L5 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Ref.16 Ref.17 Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. |
| Supplier | Cusabio |
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