| Product Name | CAB39 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to CAB39 |
| Synonyms | Cab39 antibody; CAB39_HUMAN antibody; Calcium binding protein 39 antibody; Calcium-binding protein 39 antibody; CGI 66 antibody; CGI-66 antibody; CGI66 antibody; MO25 alpha antibody; MO25 antibody; Mouse protein 25 alpha antibody; Protein Mo25 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthetic peptide of human CAB39 |
| Isotype | IgG |
| Target | CAB39 |
| Reactivity | Human, Mouse |
| Applications | ELISA, IHC, WB |
| Form | Liquid |
| Diluent Buffer | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Uniprot | Q9Y376 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | Peutz-Jeghers Syndrome (PJS) is a rare hereditary disease characterized by melanocytic macules of the lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. The serine/threonine kinase LKB1 (also designated STK11) has been identified as the gene mutated in PJS. LKB1 activity increases upon the binding of a regulatory complex consisting of the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase and the calcium binding protein 39 (MO25 alpha). STRAD and MO25 determine the subcellular localization of LKB1 by initiating its translocation from the nucleus to the cytoplasm, thus regulating the tumor suppressor activity of LKB1. The LKB1/STRAD/MO25 complex acts as an AMP-activated protein kinase kinase (AMPKK). |
| Supplier | Cusabio |
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