| Product Name | CABLES1 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to CABLES1 |
| Synonyms | CABL1_HUMAN antibody; CABLES antibody; Cables1 antibody; Cdk5 and Abl enzyme substrate 1 antibody; CDK5 and ABL1 enzyme substrate 1 antibody; FLJ35924 antibody; HsT2563 antibody; IK3 1 antibody; Ik3-1 antibody; Interactor with CDK3 1 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthesized peptide derived from internal of human Ik3-1. |
| Isotype | IgG |
| Target | CABLES1 |
| Reactivity | Human, Mouse |
| Applications | ELISA, WB |
| Form | liquid |
| Diluent Buffer | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot | Q8TDN4 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background |
Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death By similarity. Ota T., Nat. Genet. 36:40-45(2004). Nusbaum C., Nature 437:551-555(2005). Wu C.-L., Cancer Res. 61:7325-7332(2001). |
| Supplier | Cusabio |
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