| Product Name | CALCOCO1 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to CALCOCO1 |
| Synonyms | CALCOCO1 antibody; KIAA1536 antibody; PP13275 antibody; UNQ2436/PRO4996Calcium-binding and coiled-coil domain-containing protein 1 antibody; Calphoglin antibody; Coiled-coil coactivator protein antibody; Sarcoma antigen NY-SAR-3 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Recombinant human Calcium-binding and coiled-coil domain-containing protein 1 protein (462-691AA) |
| Isotype | IgG |
| Target | CALCOCO1 |
| Reactivity | Human |
| Applications | ELISA, IHC |
| Form | Liquid |
| Diluent Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Uniprot | Q9P1Z2 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). |
| Supplier | Cusabio |
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