| Product Name | Calsequestrin 2 Monoclonal Antibody |
|---|---|
| Description | Calsequestrin (CASQ) is a Ca2+-binding protein present primarily in junctional sarcoplasmic reticulum of skeletal and cardiac muscle; the cardiac form (CASQ2) is encoded by a separate gene. The primary role of CASQ2 is buffering of the sarcoplasmic reticulum Ca2+ ions,but another role for CASQ2 has emerged recently: CASQ2 regulates the open probability of ryanodine receptor 2 (RyR2). Mutations in CASQ2 cause stress-induced polymorphic ventricular tachycardia,also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2),a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest. |
| Synonyms | Calsequestrin 2,CASQ2,FLJ26321,FLJ93514,PDIB2 |
| Host | Mouse |
| Clone | 1C10A1 |
| Immunogen | Fusion Protein of Calsequestrin 2 |
| Isotype | IgG2a |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IHC, WB |
| Form | PBS with 0.02% sodium azide, 50% glycerol, PH7.3 |
| Uniprot | O14958 |
| Background | Calsequestrin (CASQ) is a Ca2+-binding protein present primarily in junctional sarcoplasmic reticulum of skeletal and cardiac muscle; the cardiac form (CASQ2) is encoded by a separate gene. The primary role of CASQ2 is buffering of the sarcoplasmic reticulum Ca2+ ions,but another role for CASQ2 has emerged recently: CASQ2 regulates the open probability of ryanodine receptor 2 (RyR2). Mutations in CASQ2 cause stress-induced polymorphic ventricular tachycardia,also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2),a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest. |
| Supplier | Elabscience |
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