| Product Name | Camostat mesylate |
|---|---|
| Description | Camostat is an orally active serine protease inhibitor which can inhibit plasmin, kallikrein, thrombin and trypsin, and attenuate pancreatic fibrosis in vivo. Camostat also inhibits influenza virus replication in human tracheal epithelial cells and reduces infection of Calu-3 lung cells by SARS-CoV-2 through inhibition of the serine protease TMPRSS2, required for viral spike protein priming. In mice, camostat was effective in protecting against death following a lethal SARS-CoV infection, with a survival rate of 60%. |
| Synonyms | 59721-29-8, CV-001, CV001, Camostat, SARS-CoV , TMPRSS2, kallikrein, plasmin, serine protease inhibitor, thrombin, trypsin |
| Molecular Weight | 494.5 Da |
| Target | Serine proteases |
| Amino Acid Sequence | 4-2-2-dimethylamino-2-oxoethoxy-2-oxoethylphenyl 4-guanidinobenzoate, methanesulfonic acid salt |
| Form | Off-white powder |
| Purity | >98% by HPLC |
| Cas Number | 59721-29-8 |
| Storage | Store desiccated, frozen and in the dark |
| References |
Ishikura et al (2007) The proteinase inhibitor camostat mesilate suppresses pancreatic pain in rodents. Life Sci. 80 1999 PMID: 17433371Hoffmann et al (2020) SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically-proven protease inhibitor. Cell 181 271 PMID: 32142651Uno (2020) Camostat mesilate therapy for COVID-19. Intern. Emerg. Med. Apr 29 1 doi: 10.1007/s11739-020-02345-9. Epub ahead of print. PMID: 32347443 Related areasAll small molecules >All serine protease modulators >All antiviral agents > |
| Supplier | Isca Biochemicals Limited |
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