| Product Name | CASP3 Monoclonal Antibody |
|---|---|
| Description | Casp3 (caspase 3),also named as CPP32,SCA-1 and Apopain,belongs to the peptidase C14A family. Caspase 3 is involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Caspase 3 cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6,-7 and -9. CASP3 is involved in the cleavage of huntingtin. This antibody can recognize the 32 kDa pro-caspase 3 as well as 17 and 19 kDa cleaved-caspase 3. |
| Synonyms | Apopain,CASP 3,CASP3,Caspase 3,Caspase3,CPP 32,CPP32,CPP32B,Cysteine protease CPP32,Protein Yama,SCA 1,SREBP cleavage activity 1 |
| Host | Mouse |
| Clone | 1E7F9 |
| Immunogen | Fusion Protein of CASP3 |
| Isotype | IgG2b |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, WB |
| Form | PBS with 0.1% sodium azide, 50% glycerol, PH7.3 |
| Uniprot | P42574 |
| Background | Casp3 (caspase 3),also named as CPP32,SCA-1 and Apopain,belongs to the peptidase C14A family. Caspase 3 is involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Caspase 3 cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6,-7 and -9. CASP3 is involved in the cleavage of huntingtin. This antibody can recognize the 32 kDa pro-caspase 3 as well as 17 and 19 kDa cleaved-caspase 3. |
| Supplier | Elabscience |
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