| Product Name | CaV_2_2 Polyclonal Antibody |
|---|---|
| Description | Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms. CACNA2D2 (Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 2) is a Protein Coding gene. Diseases associated with CACNA2D2 include Epileptic Encephalopathy, Early Infantile, 15 and Infantile Epileptic Encephalopathy. Among its related pathways are CCR5 Pathway in Macrophages and PEDF Induced Signaling. GO annotations related to this gene include voltage-gated calcium channel activity and calcium channel regulator activity. An important paralog of this gene is CACNA2D1. |
| Host | Rabbit |
| Immunogen | Synthetic Peptide |
| Isotype | IgG |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, WB |
| Form | PBS with 0.02% sodium azide, 50% glycerol, pH7.4 |
| Uniprot | Q9NY47 |
| Background |
Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms. CACNA2D2 (Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 2) is a Protein Coding gene. Diseases associated with CACNA2D2 include Epileptic Encephalopathy, Early Infantile, 15 and Infantile Epileptic Encephalopathy. Among its related pathways are CCR5 Pathway in Macrophages and PEDF Induced Signaling. GO annotations related to this gene include voltage-gated calcium channel activity and calcium channel regulator activity. An important paralog of this gene is CACNA2D1. |
| Supplier | Elabscience |
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