| Product Name | CCDC88A Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to CCDC88A |
| Synonyms | AKT iphosphorylation enhancer antibody; Akt phosphorylation enhancer antibody; APE antibody; Ccdc88a antibody; Coiled coil domain containing 88A antibody; Coiled coil domain containing protein 88A antibody; Coiled-coil domain-containing protein 88A antibody; FLJ10392 antibody; G alpha interacting vesicle associated protein antibody; G alpha-interacting vesicle-associated protein antibody; Galpha interacting vesicle associated protein antibody; Girders of actin filament antibody; Girdin antibody; GIV antibody; GRDN antibody; GRDN_HUMAN antibody; HkRP1 antibody; Hook related protein 1 antibody; Hook-related protein 1 antibody; KIAA1212 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthesized peptide derived from Internal of human Girdin. |
| Isotype | IgG |
| Target | CCDC88A |
| Reactivity | Human, Mouse |
| Applications | ELISA, IHC |
| Form | liquid |
| Diluent Buffer | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot | Q3V6T2 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background |
Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation By similarity. Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome. Enomoto A., Dev. Cell 9:389-402(2005). Simpson F., Traffic 6:442-458(2005). Hillier L.W., Nature 434:724-731(2005). |
| Supplier | Cusabio |
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