| Product Name | CD160, 27-159aa, Human, Baculovirus |
|---|---|
| Description | CD160, also known as CD160 antigen, is a human natural killer (NK)-cell-activating receptor that is also expressed on T-cell subsets. It is a tumor-specific antigen known to mediate cellular activation signals in CLL, and is a novel target for therapeutic manipulation and monitoring of minimal residual disease. It was identified as a T cell coinhibitory molecule that interacts with the herpesvirus entry mediator (HVEM) on antigen-presenting cells to deliver a potent inhibitory signal to CD4(+) T cells. Recombinant human CD160, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Synonyms | CD160 antigen, CD160, BY55, NK1, NK28 |
| Host | Virus |
| Molecular Weight |
47.7kDa (423aa) 40-57kDa (SDS-PAGE under reducing conditions.) |
| Amino Acid Sequence | ADLINITSSA SQEGTRLNLI CTVWHKKEEA EGFVVFLCKD RSGDCSPETS LKQLRLKRDP GIDGVGEISS QLMFTISQVT PLHSGTYQCC ARSQKSGIRL QGHFFSILFT ETGNYTVTGL KQRQHLEFSH NEGTLSHHHH HH |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
| Concentration | 1.0mg/ml (determined by Absorbance at 280nm) |
| Purity | > 90% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Farren TW., et al. (2011) Blood. 118:2174-2183. Kojima R., et al. (2011) J Mol Biol. 413:762-772. |
| Background | CD160, also known as CD160 antigen, is a human natural killer (NK)-cell-activating receptor that is also expressed on T-cell subsets. It is a tumor-specific antigen known to mediate cellular activation signals in CLL, and is a novel target for therapeutic manipulation and monitoring of minimal residual disease. It was identified as a T cell coinhibitory molecule that interacts with the herpesvirus entry mediator (HVEM) on antigen-presenting cells to deliver a potent inhibitory signal to CD4(+) T cells. Recombinant human CD160, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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