| Product Name | CD163, 42-1050aa, Human, Baculovirus |
|---|---|
| Description | CD163, also known as scavenger receptor cysteine-rich type 1 protein M130 isoform a, is a scavenger receptor for the hemoglobin-haptoglobin complex that is essential in liver, spleen and circulation. This protein is generated by ectodomain shedding of the membrane bound receptor. Also, it is upregulated in a large range of inflammatory diseases including liver cirrhosis, macrophage activation syndrome, HIV infection and sepsis. Recombinant human CD163, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Synonyms | Scavenger receptor cysteine-rich type 1 protein M130 isoform, CD163, M130, MM130, SCARI1 |
| Host | Virus |
| Molecular Weight | 49.5 kDa (457aa) confirmed by MALDI-TOF |
| Amino Acid Sequence | SSLGGTDKEL RLVDGENKCS GRVEVKVQEE WGTVCNNGWS MEAVSVICNQ LGCPTAIKAP GWANSSAGSG RIWMDHVSCR GNESALWDCK HDGWGKHSNC THQQDAGVTC SDGSNLEMRL TRGGNMCSGR IEIKFQGRWG TVCDDNFNID HASVICRQLE CGSAVSFSGS SNFGEGSGPI WFDDLICNGN ESALWNCKHQ GWGKHNCDHA EDAGVICSKG ADLSLRLVDG VTECSGRLEV RFQGEWGTIC DDGWDSYDAA VACKQLGCPT AVTAIGRVNA SKGFGHIWLD SVSCQGHEPA IWQCKHHEWG KHYCNHNEDA GVTCSDGSDL ELRLRGGGSR CAGTVEVEIQ RLLGKVCDRG WGLKEADVVC RQLGCGSALK TSYQVYSKIQ ATNTWLFLSS CNGNETSLWD CKNWQWGGLT CDHYEEAKIT CSAHREPRLV GGDIPCSGRV EVKHGDTWGS ICDSDFSLEA ASVLCRELQC GTVVSILGGA HFGEGNGQIW AEEFQCEGHE SHLSLCPVAP RPEGTCSHSR DVGVVCSRYT EIRLVNGKTP CEGRVELKTL GAWGSLCNSH WDIEDAHVLC QQLKCGVALS TPGGARFGKG NGQIWRHMFH CTGTEQHMGD CPVTALGASL CPSEQVASVI CSGNQSQTLS SCNSSSLGPT RPTIPEESAV ACIESGQLRL VNGGGRCAGR VEIYHEGSWG TICDDSWDLS DAHVVCRQLG CGEAINATGS AHFGEGTGPI WLDEMKCNGK ESRIWQCHSH GWGQQNCRHK EDAGVICSEF MSLRLTSEAS REACAGRLEV FYNGAWGTVG KSSMSETTVG VVCRQLGCAD KGKINPASLD KAMSIPMWVD NVQCPKGPDT LWQCPSSPWE KRLASPSEET WITCDNKIRL QEGPTSCSGR VEIWHGGSWG TVCDDSWDLD DAQVVCQQLG CGPALKAFKE AEFGQGTGPI WLNEVKCKGN ESSLWDCPAR RWGHSECGHK EDAAVNCTDI SVQKTPQKAT TGRSSRQSSH HHHHH |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in 20mM Tris-Hcl buffer (pH8.5) containing 40% glycerol, 0.1M NaCl |
| Concentration | 1mg/ml (determined by Absorbance at 280nm) |
| Purity | > 90% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Droste A., et al, (1999) Biochem. Biophys. Res. Commun. 256:110-113. Stover CM., et al, (2000) Cytogenet. Cell Genet. 90:246-247. |
| Background | CD163, also known as scavenger receptor cysteine-rich type 1 protein M130 isoform a, is a scavenger receptor for the hemoglobin-haptoglobin complex that is essential in liver, spleen and circulation. This protein is generated by ectodomain shedding of the membrane bound receptor. Also, it is upregulated in a large range of inflammatory diseases including liver cirrhosis, macrophage activation syndrome, HIV infection and sepsis. Recombinant human CD163, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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