| Product Name | Cd200r1, 26-238aa, Mouse, Baculovirus |
|---|---|
| Description | Cd200r1, also known cell surface glycoprotein CD200 receptor 1, is an isoform of CD200 receptors which is expressed on cells of the myeloid lineage. Its inhibitory signaling pathway has been implicated in playing a prominent role in limiting inflammation in a wide range of inflammatory diseases. Its signaling inhibits the expression of proinflammatory molecules including tumor necrosis factor, interferons, and inducible nitric oxide synthase in response to selected stimuli. Recombinant mouse Cd200r1, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Synonyms | Cell surface glycoprotein CD200 receptor 1, Cd200r1, CD200R, Mox2r, OX2R |
| Host | Virus |
| Molecular Weight |
37.6kDa (331aa) 40-57kDa (SDS-PAGE under reducing conditions) |
| Amino Acid Sequence | ADPTDKNQTT QNNSSSPLTQ VNTTVSVQIG TKALLCCFSI PLTKAVLITW IIKLRGLPSC TIAYKVDTKT NETSCLGRNI TWASTPDHSP ELQISAVTLQ HEGTYTCETV TPEGNFEKNY DLQVLVPPEV TYFPEKNRSA VCEAMAGKPA AQISWSPDGD CVTTSESHSN GTVTVRSTCH WEQNNVSDVS CIVSHLTGNQ SLSIELSRGG NQSLRPLEPK SCDKTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGKH HHHHH |
| Tag | His-tag |
| Reactivity | Mouse |
| Applications | SDS-PAGE |
| Form | Liquid, in Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
| Concentration | 0.25mg/ml (determined by Absorbance at 280nm) |
| Purity | > 95% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Vaine CA., et al. (2014) Adv Immunol. 121:191-211. Horie S., et al. (2013) Sci Rep. 3:3072. |
| Background | Cd200r1, also known cell surface glycoprotein CD200 receptor 1, is an isoform of CD200 receptors which is expressed on cells of the myeloid lineage. Its inhibitory signaling pathway has been implicated in playing a prominent role in limiting inflammation in a wide range of inflammatory diseases. Its signaling inhibits the expression of proinflammatory molecules including tumor necrosis factor, interferons, and inducible nitric oxide synthase in response to selected stimuli. Recombinant mouse Cd200r1, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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