| Product Name | CD206 Monoclonal Antibody |
|---|---|
| Description | CD206,also named as MMR,CLEC13D and MRC1,is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. CD206 has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses,bacteria,and fungi so that they can be neutralized by phagocytic engulfment. CD206 is a 170 kDa transmembrane protein which contains 5 domains: an amino-terminal cysteine-rich region,a fibronectin type II repeat,a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose),a transmembrane domain,and an intracellular carboxy-terminal tail. It is expressed on most tissue macrophages,in vitro derived dendritic cells,lymphatic and sinusoidal endothelia. This antibody recognizes the intracellular carboxy-terminal part of CD206 and MRC1L1. |
| Synonyms | CD206,CLEC13D,Macrophage mannose receptor 1,Mannose receptor,mannose receptor,C type 1,MMR,MRC1 |
| Host | Mouse |
| Clone | 85 |
| Immunogen | Fusion protein of Recombinant Protein |
| Isotype | IgG2a |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, WB |
| Form | PBS with 0.1% sodium azide, 50% glycerol, PH7.3 |
| Uniprot | P22897 |
| Background | CD206,also named as MMR,CLEC13D and MRC1,is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. CD206 has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses,bacteria,and fungi so that they can be neutralized by phagocytic engulfment. CD206 is a 170 kDa transmembrane protein which contains 5 domains: an amino-terminal cysteine-rich region,a fibronectin type II repeat,a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose),a transmembrane domain,and an intracellular carboxy-terminal tail. It is expressed on most tissue macrophages,in vitro derived dendritic cells,lymphatic and sinusoidal endothelia. This antibody recognizes the intracellular carboxy-terminal part of CD206 and MRC1L1. |
| Supplier | Elabscience |
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