| Product Name | CD37, 112-241aa, Human (Denatured) |
|---|---|
| Description | CD37 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. Recombinant human CD37 protein, fused to His-tag at N-terminus, was expressed in E.coli. |
| Synonyms | Leukocyte antigen CD37, Leukocyte antigen CD37, GP52-40, TSPAN26 |
| Host | E. coli |
| Molecular Weight | 15.2 kDa (138aa) confirmed by MALDI-TOF |
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSQRAQLER SLRDVVEKTI QKYGTNPEET AAEESWDYVQ FQLRCCGWHY PQDWFQVLIL RGNGSEAHRV PCSCYNLSAT NDSTILDKVI LPQLSRLGHL ARSRHSADIC AVPAESHIYR EGCAQGLQKW LHNN |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in Phosphate buffered saline (pH7.4) , 30% glycerol, 2mM DTT, 0.1mM PMSF |
| Concentration | 0.25 mg/ml (determined by Bradford assay) |
| Purity | > 90% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Draber P., et al (2011). Mol. Cell. Biol. 31:4550-4562 Classon B.J., et al (1989). J. Exp. Med. 169:1497-1502 |
| Background | CD37 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. Recombinant human CD37 protein, fused to His-tag at N-terminus, was expressed in E.coli. |
| Supplier | ARP |
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