| Product Name | CD41/Integrin alpha 2b Monoclonal Antibody |
|---|---|
| Description | The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands,cell-surface ligands,and soluble ligands . They are transmembrane __ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 _ and eight _ known subunits . In addition to mediating cell adhesion,integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration,proliferation,differentiation,and apoptosis . Integrin alpha-IIb (ITGA2B,CD41) is expressed on platelets,megakaryocytes and some hematopoietic progenitor cells . This protein undergoes post-translational cleavage to yield disulfide linked light and heavy chains which join with integrin beta3 (CD61) to form a receptor for fibronectin,fibrinogen,plasminogen,prothrombin,thrombospondin and vitronectin. Integrin alpha-IIb/beta-3 is crucial for platelet aggregation through binding of soluble fibrinogen. |
| Synonyms | CD41,CD41/Integrin alpha 2b,CD41B,GP2B,GPalpha IIb,GPIIb,GTA,HPA3,Integrin alpha IIb,ITGA2B,ITGAB |
| Host | Mouse |
| Clone | 80 |
| Immunogen | Synthetic Peptide |
| Isotype | IgG1 |
| Reactivity | Human |
| Applications | ELISA, WB |
| Form | PBS with 0.02% sodium azide, 50% glycerol, PH7.3 |
| Uniprot | P08514 |
| Background | The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands,cell-surface ligands,and soluble ligands . They are transmembrane __ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 _ and eight _ known subunits . In addition to mediating cell adhesion,integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration,proliferation,differentiation,and apoptosis . Integrin alpha-IIb (ITGA2B,CD41) is expressed on platelets,megakaryocytes and some hematopoietic progenitor cells . This protein undergoes post-translational cleavage to yield disulfide linked light and heavy chains which join with integrin beta3 (CD61) to form a receptor for fibronectin,fibrinogen,plasminogen,prothrombin,thrombospondin and vitronectin. Integrin alpha-IIb/beta-3 is crucial for platelet aggregation through binding of soluble fibrinogen. |
| Supplier | Elabscience |
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