| Product Name | CD79A, 33-143aa, Human, Baculovirus |
|---|---|
| Description | CD79A, also known as B-cell antigen receptor complex-associated protein alpha chain isoform 1, is a membrane-spanning, signal-transducing components of the B-cell receptor. It plays multiple and diverse roles in B cell development and function. It can be a cause of agammaglobulinemia. It is upregulated on MDSCs and activated in response to soluble factors secreted by tumor cells. It plays a functional role in the tumor promoting effects of myeloid cells, and may represent a novel target for cancer therapy. Recombinant human CD79A, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Synonyms | B-cell antigen receptor complex-associated protein alpha chain isoform 1, CD79A, IGA, MB-1 |
| Host | Virus |
| Molecular Weight | 50.2 kDa (456aa) confirmed by MALDI-TOF |
| Amino Acid Sequence | LWMHKVPASL MVSLGEDAHF QCPHNSSNNA NVTWWRVLHG NYTWPPEFLG PGEDPNGTLI IQNVNKSHGG IYVCRVQEGN ESYQQSCGTY LRVRQPPPRP FLDMGEGTKN RLEHHHHHH |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in 20mM Tris-Hcl buffer (pH8.0) containing 40% glycerol, 0.2M NaCl, 1mM DTT |
| Concentration | 0.25 mg/ml (determined by Absorbance at 280nm) |
| Purity | > 95% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Wang Y., et al. (2002) Am J Med Genet. 108:333-336. Luger D., et al. (2013) PLoS One. 8:e76115. |
| Background | CD79A, also known as B-cell antigen receptor complex-associated protein alpha chain isoform 1, is a membrane-spanning, signal-transducing components of the B-cell receptor. It plays multiple and diverse roles in B cell development and function. It can be a cause of agammaglobulinemia. It is upregulated on MDSCs and activated in response to soluble factors secreted by tumor cells. It plays a functional role in the tumor promoting effects of myeloid cells, and may represent a novel target for cancer therapy. Recombinant human CD79A, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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