| Product Name | CD80, 35-242aa, Human, Baculovirus |
|---|---|
| Description | CD80, also known as T-lymphocyte activation antigen CD80, is a member of cell surface immunoglobulin superfamily. This protein can bind to either human or mouse CD28 and CTLA-4. It is expressed on activated B cells, activated T cells, and macrophages. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. Therefore, it is considered a promising therapeutic target for autoimmune diseases and various carcinomas. Recombinant human CD80, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Synonyms | T-lymphocyte activation antigen CD80, CD80, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7 |
| Host | Virus |
| Molecular Weight |
32.5kDa (305aa) 28-40KDa (SDS-PAGE under reducing conditions.) |
| Amino Acid Sequence | VIHVTKEVKE VATLSCGHNV SVEELAQTRI YWQKEKKMVL TMMSGDMNIW PEYKNRTIFD ITNNLSIVIL ALRPSDEGTY ECVVLKYEKD AFKREHLAEV TLSVKADFPT PSISDFEIPT SNIRRIICST SGGFPEPHLS WLENGEELNA INTTVSQDPE TELYAVSSKL DFNMTTNHSF MCLIKYGHLR VNQTFNWNTT KQEHFPDNLE HHHHHH |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in Phosphate Buffered Saline (pH 7.4) containing 20% glycerol, 1mM DTT. |
| Concentration | 1.0mg/ml (determined by Absorbance at 280nm) |
| Purity | > 95% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Zang X., et al. (2007) Clin Cancer Res. 13:5271-5279. Kakoulidou M., et al. (2007) Scand. J. Immunol. 66:529-537. |
| Background | CD80, also known as T-lymphocyte activation antigen CD80, is a member of cell surface immunoglobulin superfamily. This protein can bind to either human or mouse CD28 and CTLA-4. It is expressed on activated B cells, activated T cells, and macrophages. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. Therefore, it is considered a promising therapeutic target for autoimmune diseases and various carcinomas. Recombinant human CD80, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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