| Product Name | CD81, 113-201aa, Human, Baculovirus |
|---|---|
| Description | CD81, also known as CD81 antigen isoform 1, belongs to the tetraspanin family. It interacts directly with immunoglobulin superfamily member 8 (IGSF8, CD316) and CD36. In B cells, it is part of a complex with CD21, CD19 and Leu13. This complex reduces the threshold for B cell activation through B cell receptors by linking Ag specific recognition and CD21 mediator recognition. On T cells it associates with CD4 and CD8 and provides a costimulatory signal with CD3. Recombinant human CD81, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Synonyms | CD81 antigen isoform 1, CD81, CVID6, S5.7, TAPA1, TSPAN28 |
| Host | Virus |
| Molecular Weight |
49.6kDa (437aa) 57-70kDa (SDS-PAGE under reducing conditions.) |
| Amino Acid Sequence | ADPFVNKDQI AKDVKQFYDQ ALQQAVVDDD ANNAKAVVKT FHETLDCCGS STLTALTTSV LKNNLCPSGS NIISNLFKED CHQKIDDLFS GKLEPKSCDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGKHHHHH H |
| Tag | hIgG-His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
| Concentration | 0.5mg/ml (determined by Absorbance at 280nm) |
| Purity | > 95% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Charrin S., et al. (2014) J. Cell. Sci. 127:3641-3648. Oren, R., et al. (1990) Mol. Cell. Biol. 10:4007-4015. |
| Background | CD81, also known as CD81 antigen isoform 1, belongs to the tetraspanin family. It interacts directly with immunoglobulin superfamily member 8 (IGSF8, CD316) and CD36. In B cells, it is part of a complex with CD21, CD19 and Leu13. This complex reduces the threshold for B cell activation through B cell receptors by linking Ag specific recognition and CD21 mediator recognition. On T cells it associates with CD4 and CD8 and provides a costimulatory signal with CD3. Recombinant human CD81, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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