| Product Name | CD8A Monoclonal Antibody,Purified |
|---|---|
| Description | Mouse monoclonal antibody to CD8A |
| Host | Mouse |
| Clonality | Monoclonal |
| Conjugate | Unconjugated |
| Isotype | IgG1 |
| Target | CD8A |
| Reactivity | Human |
| Applications | ELISA, FC |
| Form | liquid |
| Diluent Buffer | Phosphate-buffered solution, pH 7.4, containing 0.09% sodium azide |
| Uniprot | P01732 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background |
COV8 reacts with the 32 kDa a chain of CD8. This molecule is expressed on the T suppressor/cytotoxic cell population (which comprises about 1/3 of the peripheral blood T lymphocytes total population) and with most of thymocytes, as well as a subset of NK cells. CD8 expresses as either a heterodimer with the CD8b chain (CD8ab) or as a homodimer (CD8aa or CD8bb). CD8 acts as a co-receptor with MHC Class I restricted TCRs in antigen recognition. CD8 function is important for positive selection of MHC Class I restricted CD8+ T cells during T cell development 1. Engleman EG et al. (1981) J Exp Med 153: 193-198. 2. Haynes,B et al. (1986) Leukocyte TypingII: Human T lymphocytes. New York: Sprimger-Verlag; 3-30. 3. Parnes, JR. et al. (1989). Adv. Immunol. 44,256-311. 4. Bikah G. et al. (1996). Science 274:1906 |
| Supplier | Cusabio |
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