| Product Name | CDK16, 158-496aa, Human |
|---|---|
| Description | Cyclin-dependent kinase 16 isoform 1, also known as CDK16, belong to the CDK family of serine/threonine protein kinases. These proteins have a core kinase domain flanked by unique amino- and carboxy-terminal domains. CDK proteins are known to regulate the cell cycle. CDK16, which is expressed primarily in mammalian brain, interacts with a variety of proteins, and is thought to be part of a multiple signal transduction cascade. Recombinant human CDK16 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
| Synonyms | PCTAIRE, PCTAIRE1, PCTGAIRE, PCTK1 |
| Host | E. coli |
| Molecular Weight | 41.0 kDa (359aa) |
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSGFGKLET YIKLDKLGEG TYATVYKGKS KLTDNLVALK EIRLEHEEGA PCTAIREVSL LKDLKHANIV TLHDIIHTEK SLTLVFEYLD KDLKQYLDDC GNIINMHNVK LFLFQLLRGL AYCHRQKVLH RDLKPQNLLI NERGELKLAD FGLARAKSIP TKTYSNEVVT LWYRPPDILL GSTDYSTQID MWGVGCIFYE MATGRPLFPG STVEEQLHFI FRILGTPTEE TWPGILSNEE FKTYNYPKYR AEALLSHAPR LDSDGADLLT KLLQFEGRNR ISAEDAMKHP FFLSLGERIH KLPDTTSIFA LKEIQLQKEA SLRSSSMPDS GRPAFRVVDT EF |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.4M Urea |
| Concentration | 1mg/ml (determined by Bradford assay) |
| Purity | > 95% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Cheng K., et al. (2002) J Biol Chem. 277:31988-31993. Meyerson M., et al. (1992) EMBO J. 118:2909-2917. |
| Background | Cyclin-dependent kinase 16 isoform 1, also known as CDK16, belong to the CDK family of serine/threonine protein kinases. These proteins have a core kinase domain flanked by unique amino- and carboxy-terminal domains. CDK proteins are known to regulate the cell cycle. CDK16, which is expressed primarily in mammalian brain, interacts with a variety of proteins, and is thought to be part of a multiple signal transduction cascade. Recombinant human CDK16 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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