| Product Name | CDK5R1 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to CDK5R1 |
| Synonyms | CD5R1_HUMAN antibody; CDK5 activator 1 antibody; CDK5P35 antibody; CDK5R antibody; CDK5R1 antibody; Cyclin dependent kinase 5 regulatory subunit 1 antibody; Cyclin-dependent kinase 5 activator 1 antibody; Cyclin-dependent kinase 5 regulatory subunit 1 antibody; NCK 5A antibody; Neuronal CDK5 activator antibody; p23 antibody; p25 antibody; p35 antibody; Regulatory partner for CDK5 kinase antibody; Tau protein kinase II 23 kDa subunit antibody; TPKII regulatory subunit antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthesized peptide derived from internal of human CDK5R1. |
| Isotype | IgG |
| Target | CDK5R1 |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IF, WB |
| Form | liquid |
| Diluent Buffer | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot | Q15078 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background |
p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. Tsai L.-H., Nature 371:419-423(1994). Patrick G.N., Nature 402:615-622(1999). Kesavapany S., J. Neurosci. 24:4421-4431(2004). |
| Supplier | Cusabio |
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