| Product Name | CDKN2A Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to CDKN2A |
| Synonyms | CDKN2A antibody; CDKN2 antibody; MLM antibody; Tumor suppressor ARF antibody; Alternative reading frame antibody; ARF antibody; Cyclin-dependent kinase inhibitor 2A antibody; p14ARF antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthesized peptide derived from human p14 ARF antibody. |
| Isotype | IgG |
| Target | CDKN2A |
| Reactivity | Human |
| Applications | ELISA, IF, IHC, WB |
| Form | liquid |
| Diluent Buffer | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot | Q8N726 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background |
Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development. Isoform 6 may be involved in regulation of autophagy and caspase-independent cell death; the short-lived mitochondrial isoform isstabilized by C1QBP. UniProtKB Q64364 B___rice Eymin, Mol. Cell. Biol., Jun 2006; 26: 4339 - 4350. Guillaume Normand, J. Biol. Chem., Feb 2005; 280: 7118 - 7130. Abel S___hez-Aguilera, Blood, Feb 2002; 99: 1411 - 1418. Manel Esteller, Cancer Res., Apr 2001; 61: 2816 - 2821. |
| Supplier | Cusabio |
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