| Product Name | CEP131 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to CEP131 |
| Synonyms | 5 azacytidine induced 1 antibody; 5-azacytidine-induced protein 1 antibody; AZ1 antibody; Azi antibody; Azi1 antibody; AZI1_HUMAN antibody; Centrosomal protein 131 kDa antibody; Centrosomal protein of 131 kDa antibody; Cep131 antibody; KIAA1118 antibody; OTTMUSP00000004498 antibody; Pre-acrosome localization protein 1 antibody; RP23 37J21.1 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthesized peptide derived from internal of human AZI1. |
| Isotype | IgG |
| Target | CEP131 |
| Reactivity | Human, Mouse |
| Applications | ELISA, IHC, WB |
| Form | liquid |
| Diluent Buffer | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot | Q9UPN4 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background |
Component of centriolar satellites, which build a complex and dynamic network required to regulate cilia/flagellum formation. During normal and stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a p38 MAPK-dependent manner. In contrast, in proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. Acts also as a negative regulator for the trafficking from the centriolar satellite BBSome protein complex to the cilia. Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail. Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability and centriole duplication in non-ciliogenic cells. Kikuno R., DNA Res. 6:197-205(1999). Andersen J.S., Nature 426:570-574(2003). Olsen J.V., Cell 127:635-648(2006). |
| Supplier | Cusabio |
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